Objective To explore the occurrence and influencing factors of delayed nausea and vomiting in children with tumor chemotherapy，so as to provide bases for doctors and nurses to formulate home care plans. Methods A prospective cohort study was conducted，and a toll of consecutive children who received chemotherapy and their caregivers in a tertiary A Children’s Hospital in Zhejiang Province from August to October 2022 were enrolled as the subjects of investigation. Baxter Retching Faces Scale and United States Department of Health and Human Services Common Adverse Event evaluation criteria were used to evaluate the incidence of delayed nausea and vomiting. The influencing factors of delayed nausea and vomiting were collected by questionnaire and analyzed by binary logistic stepwise regression. Results A total of 378 children with tumor chemotherapy were included，of which 229（60.6%） developed delayed nausea and 144（38.1%） developed delayed vomiting. Delayed vomiting mainly occurred 1-2 days after chemotherapy（50.7%）. Logistic regression analysis showed that body surface area，negative emotion，history of delayed nausea and vomiting，and smoking environment were the influencing factors of delayed nausea in children with tumor chemotherapy. Body surface area，history of delayed nausea and vomiting，complicated with respiratory or digestive system diseases，vomiting risk of chemotherapeutic drugs，smoking environment and tumor type were the influencing factors of delayed vomiting in children with tumor chemotherapy （P<0.05）. Conclusion The incidence of nausea and vomiting associated with delayed chemotherapy was high in children with tumor，especially at 1~2 days after chemotherapy. Large body surface area，negative emotion and history of delayed nausea and vomiting are the high-risk factors of delayed nausea in children with tumor chemotherapy；large body surface area，history of delayed nausea and vomiting，complicated with respiratory or digestive system diseases，high vomiting risk of chemotherapeutic drugs and solid tumors are high risk factors for delayed vomiting in children undergoing tumor chemotherapy. It is suggested that medical staff should formulate preventive measures according to relevant risk factors and carry out home care guidance to reduce the incidence of delayed nausea and vomiting in children undergoing tumor chemotherapy.

Objective To retrieve,evaluate and integrate relevant evidence on the positioning management of preterm infants to provide clinical references. Methods We searched Guidelines International Network（GIN）,National institute for Health and Care Excellence（NICE）,Scottish Intercollegiate Guide Network（SIGN）,National Guideline Clearinghouse（NGC）,Registered Nurses’ Association of Ontario（RNAO）,Joanna Briggs Institute（JBI）,BMJ Best Practice,PubMed,Embase,OVID,Wanfang Database,CNKI,Yimaitong and other websites on all evidence on the positioning management of preterm infants,including guidelines,evidence summaries,best clinical practice manuals,clinical decision-making and systematic reviews,and the search time limit is from the establishment of the databases to August 31,2020. Results Totally 10 articles were involved,including 3 guidelines,5 systematic reviews,1 technical report and 1 clinical decision support. Finally,21 pieces of best evidence about positioning assessment,positioning the preterm infants,positioning equipment and positioning management of exceptional case were summarized. Conclusion This study summarizes the current best evidence on the positioning management of preterm infants and provides an evidence-based basis for standardizing the positioning management of preterm infants. It is recommended that medical staff should consider the clinical situation when applying the evidence,and selectively apply the best evidence to promote health of preterm infants.